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Chemotherapy basics for family physicians

Assistant Professor in the Department of Family Medicine at the University of Ottawa in Ontario, a family physician with the Ottawa Academic Family Health Team, a general practitioner oncologist at The Ottawa Hospital Cancer Centre, Program Director of PGY-3 FP-Oncology, Chair of the Cancer Care Member Interest Group at the College of Family Physicians of Canada, and Regional Cancer Primary Care Lead for Champlain Region.

Anna N. Wilkinson

Assistant Professor in the Department of Family Medicine at the University of Ottawa in Ontario, a family physician with the Ottawa Academic Family Health Team, a general practitioner oncologist at The Ottawa Hospital Cancer Centre, Program Director of PGY-3 FP-Oncology, Chair of the Cancer Care Member Interest Group at the College of Family Physicians of Canada, and Regional Cancer Primary Care Lead for Champlain Region.

Clinical Assistant Professor in the Department of Family Medicine at the University of Calgary in Alberta, a faculty member in the Department of Haematology-Oncology at Aga Khan University in Nairobi, Kenya, and Clinical Associate at Alberta Health Services in Edmonton.

Nureen Sumar

Clinical Assistant Professor in the Department of Family Medicine at the University of Calgary in Alberta, a faculty member in the Department of Haematology-Oncology at Aga Khan University in Nairobi, Kenya, and Clinical Associate at Alberta Health Services in Edmonton.

Despite the explosion of novel cancer therapies, chemotherapy remains the backbone of cancer treatment. Family physicians learn little about chemotherapy during their training, but are often required to manage toxicities of these treatments for their patients. 1 This brief will summarize chemotherapy essentials for family physicians.

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Overview

All chemotherapy drugs work by decreasing cellular growth and proliferation. The mechanisms of these drugs vary from competitively inhibiting cross-linking DNA, to blocking enzymes involved in DNA replication (eg, topoisomerases) and impairing spindle microtubule formation ( Figure 1 ). 2 , 3 BC Cancer’s drug manual is an excellent resource for more information about chemotherapy drugs (http://www.bccancer.bc.ca/health-professionals/clinical-resources/cancer-drug-manual).

Mechanisms of action of various chemotherapy drugs

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